Air & Car
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Philadelphia International Airport
Fly into Philadelphia International Airport (PHL) and take a hotel shuttle to the Marriott.  There is also a SEPTA train that goes to the airport and then into town; it can get you fairly close to the hotel but you will need to do some walking at some point.
Alternatively, fly into Newark International Airport (EWR) and either rent a car to drive down to Philly or take a NJ Transit train to Trenton and then change to a Septa train that will bring you into Philly.  (This only makes sense if you plan to visit NYC while you're in the area, as Newark is between the two).

**please note that if you're driving, the parking at the hotel is VALET ONLY and very expensive ($48 per night).  There are plenty of parking garages within quick walking distance from the hotel; they're still fairly expensive but better than the hotel.  Hey, this is what happens in a big city, what can I say?